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Invitrogen
C1orf51 Polyclonal Antibody
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产品信息
PA5-55643
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: NTQGCTTEGD LLFAQKCKEL QGFIPPLTDL LNGLKMGRFE RGLSSFQQSV AMDRIQRIVG VLQKPQMGER YLGTLLQVEG MLKTWFPQ
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 95%.
靶标信息
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ChIP-derived repressor of network oscillator; Chrono; circadian associated repressor of transcription; Circadian-associated transcriptional repressor; Computationally highlighted repressor of the network oscillator; hypothetical gene supported by NM_017187
基因别名: C1orf51; CHRONO; CIART; GM129; RGD1566380
UniProt ID: (Human) Q8N365, (Mouse) Q3TQ03
Entrez Gene ID: (Human) 148523, (Mouse) 229599, (Rat) 365871
