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Invitrogen
C1orf74 Polyclonal Antibody
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产品信息
PA5-55879
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LLGYPVPYTF HLNQGDDNCL ALTPLRVFTA RISWLLGQPP ILLYSFSVPE SLFPGLRDIL NTWEKDLRTR FRTQNDFADL
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 76%.
靶标信息
C1orf74, also known as URCL4, is located on chromosome 1q32.2 and encodes a previously uncharacterized protein. Recent studies have revealed that C1orf74 is significantly up-regulated in various cancers, including cervical cancer and lung adenocarcinoma. The overexpression of C1orf74 is associated with poor prognosis, indicating its potential role in tumor progression and proliferation. Mechanistically, C1orf74 has been shown to positively regulate the EGFR/AKT/mTORC1 signaling pathway, which is crucial for cell growth and survival. Knockdown studies have demonstrated that reducing C1orf74 expression inhibits cancer cell growth, highlighting it as a potential therapeutic target. Additionally, C1orf74's role in immune cell infiltration suggests it may influence the tumor immune microenvironment, further implicating its importance in cancer biology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: up-regulated in lung cancer 4; UPF0739 protein C1orf74
基因别名: C1orf74; URLC4
UniProt ID: (Human) Q96LT6
Entrez Gene ID: (Human) 148304
