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Invitrogen
C1rLP Polyclonal Antibody
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产品信息
PA5-47561
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Mouse myeloma cell line NS0-derived recombinant mouse Complement Component C1rLP Ser18-Asp456
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human (rh) C1rLP is observed and less than 1% cross-reactivity with rhC1R and rhC1S is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Complement component 1, r subcomponent-like protein (C1rLP) is part of the complement system, primarily involved in innate immunity. Located on human chromosome 12p13.31, C1rLP is closely related to C1r, a serine protease component of the C1 complex in the classical pathway of complement activation. C1rLP shares structural similarities with C1r, featuring serine protease domains that are crucial for the proteolytic processing required to activate the complement cascade. The precise functional role of C1rLP remains under investigation, but it is hypothesized to act as a modulator of complement activation, potentially influencing immune cell behavior during inflammation or infection. The potential existence of several isoforms of C1rLP suggests diverse regulatory functions, which could impact processes like opsonization, pathogen clearance, and inflammation. Current research explores its relevance in immune response regulation, with implications for understanding autoimmune and inflammatory diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C1r-like protein; C1r-LP; Complement C1r subcomponent-like protein; complement component 1, r subcomponent like protein
基因别名: C1r-LP; C1rl; C1rl1; C1rlp
UniProt ID: (Mouse) Q3UZ09
Entrez Gene ID: (Mouse) 232371
