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Invitrogen
C7orf60 Polyclonal Antibody
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产品信息
PA5-65637
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QERKLEQEKLS GVVKSVHRRL RKKYREVGDF DKIWREHCED EETLCEYAVA MKNLADNHWA KTCEGEGRIE WCCSVCREYF Q
Highest antigen sequence identity to the following orthologs - mouse 99%, rat 38%.
靶标信息
S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Probable methyltransferase BMT2 homolog; S-adenosylmethionine sensor upstream of mTORC1; UPF0532 protein C7orf60
基因别名: BMT2; C7orf60; SAMTOR
UniProt ID: (Human) Q1RMZ1
Entrez Gene ID: (Human) 154743
