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Invitrogen
C8orf48 Polyclonal Antibody
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产品信息
PA5-55614
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: RDAFSCTVPD ELLNRIYFKN MRTTPKQEAA AKQHISYQCP YCNRKRAELA LSAFLKQKKT LLESFLLQER IDEHLHT
Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 25%.
靶标信息
The C8orf48 gene has been identified as a critical biomarker in colorectal cancer (CRC). Research indicates that C8orf48 plays a significant role in inhibiting tumorigenesis by regulating key signaling pathways. This gene is negatively associated with KRAS, BRAF, and MAP2K2 in normal colorectal tissues and negatively correlated with MAP2K2 in CRC tissues. These associations suggest that C8orf48 may function as a tumor suppressor by modulating pathways involved in cell proliferation, migration, and invasion. The gene's expression and methylation profiles have been extensively studied using data from The Cancer Genome Atlas (TCGA), and functional assays have confirmed its inhibitory effects on CRC cell growth. Additionally, C8orf48 has been identified as a direct target of miR-556, further elucidating its regulatory mechanisms. The findings underscore the potential of C8orf48 as a novel target for CRC prediction and therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Uncharacterized protein C8orf48
基因别名: C8orf48
UniProt ID: (Human) Q96LL4
Entrez Gene ID: (Human) 157773
