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Invitrogen
C9ORF72 Polyclonal Antibody
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C9ORF72 Antibody (PA5-114361) in WB
Western blot analysis of C9ORF72 in the following samples: Lane 1: human placenta tissue lysates, Lane 2: human U2OS whole cell lysates, Lane 3: human PC-3 whole cell lysates, Lane 4: human K562 whole cell lysates, Lane 5: human HeLA whole cell lysates, Lane 6: human A431 whole cell lysates, Lane 7: human A549 whole cell lysates. Samples consisting of 50 µg (reducing conditions) of protein was separated with 5-20% SDS-PAGE gel (70V, Stacking gel; 90V, Resolving gel; 2-3 hrs.), transferred to a Nitrocellulose membrane (150mA, 50-90 min) and... View More
产品信息
PA5-114361
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human C9ORF72 (APKTEQVLLSDGEITFLANHTLNGEILR).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human placenta tissue, human U2OS whole cell, human PC-3 whole cell, human K562 whole cell, human Hela whole cell, human A431 whole cell, human A549 whole cell, rat brain tissue, rat liver tissue, rat C6 whole cell, mouse liver tissue, mouse HEPA1-6 whole cell. Flow: U20S cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
C9orf72 may play a role in endosomal trafficking and autophagy. It is known to interact with HNRNPA1, HNRNPA2B1, UBQLN2, and small Rab GTPSases. C9orf72 localizes in the nucleus, cytoplasm, endosome, lysosome, and autophagosome. Mutations in this gene can result in frontotemporal dementia and/or amyotrophic lateral sclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Guanine nucleotide exchange factor C9orf72; Guanine nucleotide exchange factor C9orf72 homolog; protein C9orf72 homolog
基因别名: AI840585; ALSFTD; C9orf72; DENND9; DENNL72; FTDALS; FTDALS1
UniProt ID: (Mouse) Q6DFW0, (Human) Q96LT7, (Rat) Q66HC3
Entrez Gene ID: (Mouse) 73205, (Human) 203228, (Rat) 313155
