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Immunogen sequence: FSEATSSVQK GESLADSVQT MSCYADVVVL RHPQPGAVEL AAKHCRRPVI NAGDGVGEHP TQALLDIFTI REELGTVNGM TITMVGDLKH GRTVHSLACL LTQYRVSLRY VAPPSLRMPP
Antigen sequence identity: Mouse 99%; Rat 99%
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CAD trifunctional protein; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; Multifunctional protein CAD
基因别名: CAD; CDG1Z
UniProt ID: (Human) P27708
Entrez Gene ID: (Human) 790