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Invitrogen
CADM3 Recombinant Rabbit Monoclonal Antibody (3)
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产品信息
MA5-30127
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3
抗原
Recombinant Human CADM3 protein (Met1-His330)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human CADM3/NECL1/IGSF4B.
靶标信息
Cell adhesion molecule 3 (CADM3), also known as Necl-1, is a gene located on chromosome 1p36.22, encoding a protein that is part of the immunoglobulin superfamily involved in cell-cell adhesion processes. CADM3 is predominantly expressed in the nervous system, particularly in regions such as the brain and spinal cord, where it plays crucial roles in neuronal communication, synapse formation, and maintenance of neural network architecture. The protein functions by mediating homophilic and heterophilic interactions with other cell adhesion molecules, facilitating synapse stabilization and neuronal differentiation. CADM3's activity is essential for proper neural development and function, and dysregulation of its expression has been linked to various neurological disorders. Beyond its role in the nervous system, CADM3 also contributes to tumor suppression in certain cancers, as its expression is often downregulated in tumor tissues. Research into CADM3 continues to explore its potential as a therapeutic target in both neurobiology and oncology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain immunoglobulin receptor; Cell adhesion molecule 3; dendritic cell nectin-like protein 1 short isoform; IgSF4B; Immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; NECL-1; nectin-like 1; Nectin-like protein 1; Synaptic cell adhesion molecule 3; SynCAM3; TSLC1-like 1; TSLC1-like protein 1; TSLL1
基因别名: BIgR; CADM3; IGSF4B; Necl-1; NECL1; SYNCAM3; TSLL1; UNQ225/PRO258
UniProt ID: (Human) Q8N126
Entrez Gene ID: (Human) 57863
