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Invitrogen
CAF1 p150 Recombinant Rabbit Monoclonal Antibody (1T1O5)
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CAF1 p150 Antibody (MA5-38180) in WB
Western blot was performed using CAF1 p150 Recombinant Rabbit Monoclonal Antibody (ARC2011) (Product # MA5-38180) and a 150 kDa band corresponding to CAF1 p150 was observed and cell cycle dependent variation in expression was observed in HeLa cells treated with multiple treatments. Nuclear enriched extracts (30 µg lysate) of K-562 (Lane 1), A-431 (Lane 2), Hep G2 (Lane 3), HeLa (Lane 4), HeLa (G1 phase) 25h block in 2mm thymidine; 12h release in 30 µm 2-deoxycytidine, 25h block in 2mm thymidine followed by 14h release in 30 µm 2-deoxycytid... View More
产品信息
MA5-38180
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1T1O5
抗原
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human p150 CAF1 (NP_0054742)
偶联物
形式
Liquid
浓度
0.14 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: HeLa, Jurkat, SH-SY5Y
Immunogen sequence: NFLRNRIETS IGQSTVIIDL TEDSNEQPDS LVDHNKLNSE ASPSREAING QREDTGDQQG LLKAIQNDKL AFPGETLSDI PCKTEEEGVG CGGAGRRGDS Q
靶标信息
CAF1 p150 is part of the chromatin assembly factor 1 (CAF-1) complex, a key player in DNA repair and replication processes. CAF-1, composed of p150 (CHAF1A), p60 (CHAF1B), and p48 subunits, functions primarily in the deposition of newly synthesized histones H3 and H4 onto nascent DNA strands, ensuring chromatin is properly assembled during DNA replication and after repair. The p150 subunit is the largest of the CAF-1 complex and is critical for binding DNA and recruiting CAF-1 to replication sites, facilitating histone deposition in a process vital for maintaining genome stability and epigenetic inheritance. Beyond just chromatin formation, CAF1 p150 is involved in influencing gene silencing and the maintenance of heterochromatin, impacting gene regulation notably during development and in response to DNA damage. Its role has implications in oncogenesis, where dysregulation of CAF1 p150 can lead to altered chromatin structures and contribute to tumorigenesis, marking it as an important target in cancer research.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; Chromatin assembly factor 1 subunit A; chromatin assembly factor 1, subunit A (p150); chromatin assembly factor I (150 kDa); Chromatin assembly factor I p150 subunit; CTB-50L17.7; hp150; MGC71229
基因别名: CAF; CAF-1; CAF1; CAF1B; CAF1P150; CHAF1A; P150
UniProt ID: (Human) Q13111
Entrez Gene ID: (Human) 10036
