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Invitrogen
CALCRL Recombinant Rabbit Monoclonal Antibody (8H9L8)
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CALCRL Antibody (703811) in IHC
Sections of Rat dorsal root ganglia were dewaxed, microwaved in citric acid and incubated with Anti-CALCRL Recombinant Rabbit Monoclonal Antibody (Product # 703811, 1:500 dilution). Sections were then sequentially treated with biotinylated anti-rabbit IgG and AB solution. Sections were then developed in AEC and lightly counterstained with hematoxylin. Note, strong staining of small to medium diameter neurons. Inset, peptide neutralization control.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
703811
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8H9L8
抗原
Peptides corresponding to human CALCRL [1) aa23-aa40 2) aa48-aa64]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Mouse, Bovine.
靶标信息
CRLR is a receptor for calcitonin gene-related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-cell/lung/testis, bome marrow, embryo, lung and synovium libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Calcitonin gene-related peptide type 1 receptor; Calcitonin receptor-like receptor; CGRP receptor; CGRP type 1 receptor; Cgrp1 receptor; CRLR
基因别名: CALCRL; CGRPR; CLR; Crlr; RATCRLR; RNCLR
UniProt ID: (Rat) Q63118
Entrez Gene ID: (Rat) 25029
angiogenesis
cAMP biosynthetic process
calcium ion transport
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
heart development
positive regulation of cell proliferation
protein transport
positive regulation of cAMP biosynthetic process
receptor internalization
negative regulation of smooth muscle contraction
positive regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
cellular response to sucrose stimulus
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