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Invitrogen
CALM Polyclonal Antibody
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CALM Antibody (PA5-115756) in IHC (P)
Immunohistochemistry analysis of CALM in human kidney cancer and adjacent normal tissues. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115756) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
产品信息
PA5-115756
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PICALM(Accession Q13492), corresponding to amino acid residues M617-M652.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total PICALM.
靶标信息
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CALM; Clathrin assembly lymphoid myeloid leukemia; Clathrin assembly lymphoid myeloid leukemia protein; clathrin-assembly lymphoid leukemia protein; clathrin-assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly protein; rCALM
基因别名: CALM; CLTH; fit-1; Fit1; LAP; mKIAA4114; PAP180; PICALM
UniProt ID: (Human) Q13492, (Mouse) Q7M6Y3, (Rat) O55012
Entrez Gene ID: (Human) 8301, (Mouse) 233489, (Rat) 89816
protein complex assembly
receptor-mediated endocytosis
cell proliferation
negative regulation of gene expression
synaptic vesicle maturation
vesicle-mediated transport
endosomal transport
regulation of endocytosis
receptor internalization
regulation of protein localization
cargo loading into vesicle
positive regulation of transcription, DNA-templated
negative regulation of receptor-mediated endocytosis
clathrin coat assembly
iron ion homeostasis
clathrin-mediated endocytosis
iron ion import into cell
cell-cell adhesion
positive regulation of neuron death
positive regulation of beta-amyloid formation
regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
endocytosis
multicellular organism development
axonogenesis
hemopoiesis
dendrite morphogenesis
regulation of protein transport
