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Invitrogen
CALM Recombinant Rabbit Monoclonal Antibody (9H3)
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CALM Antibody (MA573380) in IHC (P)
Immunohistochemistry analysis of CALM on paraffin-embedded Human Lung Cancer tissue. Antigen retrieval by boiling in sodium citrate buffer (pH 6.0) for 15 min. Samples were incubated with CALM Recombinant Monoclonal (Product # MA573380) using a dilution at 1:200 overnight at 4°C. Followed by DAB staining.
产品信息
MA573380
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
9H3
抗原
KLH conjugated synthetic peptide derived from human PICALM.
偶联物
形式
Liquid
浓度
0.3 mg/mL
规格
30 µg
纯化类型
Protein A
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Clathrin assembly lymphoid myeloid leukemia protein; Phosphatidylinositol-binding clathrin assembly protein; unnamed protein product
基因别名: CALM; CLTH; LAP; PICALM
UniProt ID: (Human) Q13492
Entrez Gene ID: (Human) 8301
SNARE binding
beta-amyloid binding
protein binding
phospholipid binding
1-phosphatidylinositol binding
phosphatidylinositol-4,5-bisphosphate binding
clathrin binding
small GTPase binding
clathrin heavy chain binding
cadherin binding
tau protein binding
low-density lipoprotein particle receptor binding
cellular iron ion homeostasis
endocytosis
receptor-mediated endocytosis
membrane budding
axonogenesis
learning or memory
negative regulation of gene expression
synaptic vesicle maturation
vesicle-mediated transport
endosomal transport
hemopoiesis
regulation of endocytosis
receptor internalization
regulation of protein localization
cargo loading into vesicle
positive regulation of transcription, DNA-templated
positive regulation of Ras protein signal transduction
regulation of receptor-mediated endocytosis
negative regulation of receptor-mediated endocytosis
clathrin coat assembly
dendrite morphogenesis
multicellular organismal iron ion homeostasis
protein-containing complex assembly
clathrin-mediated endocytosis
regulation of vesicle size
membrane bending
amyloid-beta clearance by transcytosis
regulation of beta-amyloid formation
positive regulation of beta-amyloid formation
regulation of amyloid precursor protein catabolic process
positive regulation of amyloid precursor protein catabolic process
negative regulation of protein localization to plasma membrane
negative regulation of protein localization to cell surface
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