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Abnova
CALR3 Polyclonal Antibody, MaxPab™
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产品信息
H00125972-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CALR3 (NP_659483.1, 1 a.a. approximately 384 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MARALVQFWA ICMLRVALAT VYFQEEFLDG EHWRNRWLQS TNDSRFGHFR LSSGKFYGHK EKDKGLQTTQ NGRFYAISAR FKPFSNKGKT LVIQYTVKHE QKMDCGGGYI KVFPADIDQK NLNGKSQYYI MFGPDICGFD IKKVHVILHF KNKYHENKKL IRCKVDGFTH LYTLILRPDL SYDVKIDGQS IESGSIEYDW NLTSLKKETS PAESKDWEQT KDNKAQDWEK HFLDASTSKQ SDWNGDLDGD WPAPMLQKPP YQDGLKPEGI HKDVWLHRKM KNTDYLTQYD LSEFENIGAI GLELWQVRSG TIFDNFLITD DEEYADNFGK ATWGETKGPE REMDAIQAKE EMKKAREEEE EELLSGKINR HEHYFNQFHR RNEL
靶标信息
Calreticulin 3 (CALR3) is a gene located on chromosome 19p13.11, encoding a member of the calreticulin family of calcium-binding chaperones. Unlike the more ubiquitously expressed calreticulin (CALR), CALR3 is specifically expressed in the testes and plays a crucial role in spermatogenesis. CALR3 is involved in the quality control of proteins within the endoplasmic reticulum (ER) and assists in the folding and assembly of newly synthesized glycoproteins. This protein's function is essential for the maturation of sperm cells and male fertility, as it helps ensure the proper formation and function of sperm-specific proteins. Mutations in CALR3 have been associated with familial hypertrophic cardiomyopathy, reflecting its potential involvement in cardiac muscle function through mechanisms that remain to be fully elucidated. Research continues to explore CALR3's specific roles in reproductive biology and its implications in hereditary conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calreticulin-2; Calreticulin-3; Calsperin; cancer/testis antigen 93; testis secretory sperm-binding protein Li 226n
基因别名: CALR3; CMH19; CRT2; CT93
UniProt ID: (Human) Q96L12
Entrez Gene ID: (Human) 125972
