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Invitrogen
CAMLG Polyclonal Antibody
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CAMLG Antibody (PA5-103675) in IHC (P)
Immunohistochemistry analysis of CAMLG in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with CAMLG polyclonal antibody (Product # PA5-103675) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-103675
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CAMLG(Accession P49069), corresponding to amino acid residues K209-R259.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CAMLG.
靶标信息
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium signal-modulating cyclophilin ligand; calcium-modulating cyclophilin ligand; cyclophilin B-binding protein; Guided entry of tail-anchored proteins factor CAMLG; unnamed protein product
基因别名: CAML; CAMLG; CDG2Z; GET2
UniProt ID: (Human) P49069
Entrez Gene ID: (Human) 819
B cell homeostasis
receptor recycling
defense response
signal transduction
epidermal growth factor receptor signaling pathway
vesicle-mediated transport
negative regulation of protein ubiquitination
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
protein insertion into ER membrane
protein stabilization
tail-anchored membrane protein insertion into ER membrane
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