Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
CARD10 Recombinant Rabbit Monoclonal Antibody (HL2261)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 4
CARD10 Antibody (MA5-50464) in WB
Western Blot analysis of CARD10 using CARD10 Recombinant Monoclonal Antibody (Product # MA5-50464) in A431 (30 μg) and HeLa (30 μg) whole cell extracts at a dilution of 1:1,000. Extracts were separated by 7.5% SDS-PAGE. An HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
MA5-50464
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2261
抗原
Recombinant fragment of human CARD10.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-Kappa-B activation. When expressed in cells, this protein binds to BCL10 and activates NF-Kappa-B Recent experiments have shown that CARMA3 is required for EGF-induced NF-Kappa-B activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Bcl10 binding protein and activator of NFKB; Bcl10-interacting MAGUK protein 1; Bimp1; CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; Carma 3; caspase recruitment domain family, member 10; Caspase recruitment domain-containing protein 10
基因别名: AI449026; BIMP1; CARD10; CARMA3
UniProt ID: (Human) Q8NC81, (Mouse) P58660
Entrez Gene ID: (Human) 29775, (Mouse) 105844, (Rat) 315120
