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Abnova
CARD14 Polyclonal Antibody, MaxPab™
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产品信息
H00079092-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CARD14 (NP_438170.1, 1 a.a. approximately 434 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MVSSCELELQ EQSLRTASDQ ESGDEELNRL KEENEKLRSL TFSLAEKDIL EQSLDEARGS RQELVERIHS LRERAVAAER QREQYWEEKE QTLLQFQKSK MACQLYREKV NALQAQVCEL QKERDQAYSA RDSAQREISQ SLVEKDSLRR QVFELTDQVC ELRTQLRQLQ AEPPGVLKQE ARTREPCPRE KQRLVRMHAI CPRDDSDCSL VSSTESQLLS DLSATSSREL VDSFRSSSPA PPSQQSLYKR VAEDFGEEPW SFSSCLEIPE GDPGALPGAK AGDPHLDYEL LDTADLPQLE SSLQPVSPGR LDVSESGVLM RRRPARRILS QVTMLAFQGD ALLEQISVIG GNLTGIFIHR VTPGSAADQM ALRPGTQIVM VSRARPLLSP GLLMGTVAAG GVTQADFTSP RRCRSTLGWA SALSWADVKR SAHL
靶标信息
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase. CARD 14 is expressed in the placenta where it positively regulates apoptosis. CARD 14 also controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex. Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bcl10-interacting maguk protein 2; CARD-containing MAGUK protein 2; Carma 2; caspase recruitment domain family, member 14; Caspase recruitment domain-containing protein 14
基因别名: BIMP2; CARD14; CARMA2; PRP; PSORS2; PSS1
UniProt ID: (Human) Q9BXL6
Entrez Gene ID: (Human) 79092
