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Invitrogen
CATSPER3 Polyclonal Antibody
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Product Details
PA5-50374
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein corresponding to a region derived from internal residues of human cation channel, sperm associated 3
Conjugate
Form
Liquid
Concentration
1.3 mg/mL
Amount
130 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total CATSPER3 protein.
Target Information
CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins contain a single, six-transmembrane-spanning segment and exhibit the voltage-dependent Ca2+ channel four-repeat structure. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. Mutations in any of the genes encoding CatSper family proteins can result in male infertility. CatSper3 plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca(v)-like protein; calcium channel repeat containing 1; Cation channel sperm-associated protein 3; CatSper3; One-repeat calcium channel-like protein; putative ion channel CatSper3; unnamed protein product
Gene Aliases: 4921522D01Rik; CACRC; CATSPER3
UniProt ID: (Human) Q86XQ3, (Mouse) Q80W99
Entrez Gene ID: (Human) 347732, (Mouse) 76856
ion transport
sodium ion transport
calcium ion transport
spermatogenesis
cell differentiation
sperm motility
ion transmembrane transport
sperm capacitation
establishment of localization in cell
transmembrane transport
calcium ion transmembrane transport
transport
multicellular organism development
regulation of ion transmembrane transport
calcium ion import
membrane depolarization during action potential
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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