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          • Primary Antibodies ›
          • CBP/p300 Antibodies

          Invitrogen

          CBP/p300 Polyclonal Antibody

          查看其他2个CBP/p300抗体

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          Cite CBP/p300 Polyclonal Antibody

          Additional Information:
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          • 抗体检测数据 (1)
          CBP/p300 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.
          CBP/p300 Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          图: 1 / 1

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          CBP/p300 Antibody (PA5-99492) in WB

          Western blot analysis of CBP/p300 in COLO205 cell lysate (left lane: treated with the antigen-specific peptide). Samples were incubated with CBP/p300 polyclonal antibody (Product # PA5-99492). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          CBP/p300 Antibody in Western Blot (WB)
          CBP/p300 Polyclonal Antibody

          产品信息

          PA5-99492

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:2,000
          -

          免疫组化(石蜡) (IHC (P))

          1:50-1:200
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          A synthesized peptide derived from human EP300(Accession Q09472), corresponding to amino acid residues K1549-R1599.
          3D表位/免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1 mg/mL

          规格

          100 µg

          纯化类型

          Affinity chromatography

          保存液

          PBS, pH 7.4, with 50% glycerol

          内含物

          0.02% sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2818425

          产品详细信息

          Antibody detects endogenous levels of total P300/CBP.

          靶标信息

          This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: CBP; CREBBP; CREB-binding protein; E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; Histone lysine acetyltransferase CREBBP; p300 HAT; Protein 2-hydroxyisobutyryltransferase p300; Protein isonicotinyltransferase p300; Protein lactyltransferas CREBBP; Protein lactyltransferas p300; Protein propionyltransferase p300; Protein-lysine acetyltransferase CREBBP; unnamed protein product

          查看更多 收起

          基因别名: A430090G16; A730011L11; AW558298; CBP; CBP/p300; CREBBP; EP300; KAT3A; KAT3B; MKHK1; MKHK2; P300; p300 HAT; p300/CBP; RSTS; RSTS1; RSTS2; RTS

          查看更多 收起

          UniProt ID: (Human) Q92793, (Human) Q09472, (Mouse) B2RWS6

          查看更多 收起

          Entrez Gene ID: (Human) 1387, (Mouse) 12914, (Rat) 54244, (Human) 2033, (Mouse) 328572, (Rat) 170915

          查看更多 收起

          功能
          transcription coactivator binding p53 binding chromatin binding damaged DNA binding transcription cofactor activity transcription coactivator activity transcription corepressor activity histone acetyltransferase activity protein binding zinc ion binding acetyltransferase activity transferase activity transferase activity, transferring acyl groups chromatin DNA binding MRF binding histone acetyltransferase activity (H3-K18 specific) histone acetyltransferase activity (H3-K27 specific) metal ion binding tau protein binding RNA polymerase II sequence-specific DNA binding transcription factor binding peptide-lysine-N-acetyltransferase activity peptide lactyltransferase (CoA-dependent) activity DNA-binding transcription factor binding RNA polymerase II regulatory region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding transcriptional repressor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding activating transcription factor binding peroxisome proliferator activated receptor binding SMAD binding transcription cofactor binding lysine N-acetyltransferase activity, acting on acetyl phosphate as donor beta-catenin binding H3 histone acetyltransferase activity H4 histone acetyltransferase activity ligand-dependent nuclear receptor binding histone H2B acetyltransferase activity androgen receptor binding NF-kappaB binding protein propionyltransferase activity pre-mRNA intronic binding STAT family protein binding peptide 2-hydroxyisobutyryltransferase activity histone lactyltransferase (CoA-dependent) activity acetylation-dependent protein binding peptide crotonyltransferase activity peptide butyryltransferase activity histone crotonyltransferase activity histone butyryltransferase activity histone reader activity histone H3K122 acetyltransferase activity RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter binding RNA polymerase II activating transcription factor binding core promoter proximal region DNA binding antigen binding protein C-terminus binding protein kinase binding protein complex binding nuclear hormone receptor binding glucocorticoid receptor binding bHLH transcription factor binding mitogen-activated protein kinase binding protein antigen binding histone modifying enzyme
          参与通路
          negative regulation of transcription from RNA polymerase II promoter double-strand break repair via homologous recombination response to hypoxia stimulatory C-type lectin receptor signaling pathway chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein acetylation signal transduction I-kappaB kinase/NF-kappaB signaling regulation of smoothened signaling pathway negative regulation of transcription from RNA polymerase I promoter N-terminal peptidyl-lysine acetylation positive regulation of transforming growth factor beta receptor signaling pathway protein destabilization cellular response to nutrient levels cellular response to UV homeostatic process embryonic digit morphogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process protein stabilization protein-containing complex assembly protein K48-linked deubiquitination energy homeostasis regulation of cellular response to heat positive regulation of protein localization to nucleus positive regulation of double-strand break repair via homologous recombination transcription, DNA-templated transcription from RNA polymerase II promoter cell proliferation histone acetylation germ-line stem cell population maintenance positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of G1/S transition of mitotic cell cycle response to interleukin-1 autophagosome assembly somitogenesis thigmotaxis behavioral defense response gluconeogenesis glycolytic process regulation of glycolytic process internal protein amino acid acetylation apoptotic process JAK-STAT cascade nervous system development heart development skeletal muscle tissue development learning or memory circadian rhythm lipid biosynthetic process organ morphogenesis regulation of autophagy negative regulation of autophagy positive regulation of gene expression regulation of mitochondrion organization positive regulation of neuron projection development internal peptidyl-lysine acetylation B cell differentiation platelet formation lung development negative regulation of protein complex assembly negative regulation of protein oligomerization multicellular organism growth megakaryocyte development endodermal cell differentiation swimming TORC1 signaling TORC2 signaling positive regulation of protein import into nucleus intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator protein kinase B signaling response to estrogen positive regulation by host of viral transcription fat cell differentiation negative regulation of gluconeogenesis positive regulation of gene expression, epigenetic positive regulation of JAK-STAT cascade positive regulation of protein kinase B signaling canonical Wnt signaling pathway face morphogenesis regulation of androgen receptor signaling pathway peptidyl-lysine propionylation protein localization to chromatin cellular response to leucine tricarboxylic acid metabolic process T-helper 17 cell lineage commitment regulation of tubulin deacetylation peptidyl-lysine crotonylation peptidyl-lysine butyrylation regulation of signal transduction by p53 class mediator positive regulation of TORC1 signaling positive regulation of TORC2 signaling positive regulation of T-helper 17 cell lineage commitment positive regulation of protein phosphorylation positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response cell cycle response to glucose positive regulation of glycoprotein biosynthetic process positive regulation of cell death positive regulation of muscle atrophy cell differentiation positive regulation of cell growth negative regulation of cellular metabolic process positive regulation of cellular metabolic process positive regulation of protein binding positive regulation of collagen biosynthetic process positive regulation of protein import into nucleus, translocation positive regulation of histone acetylation response to drug negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of DNA binding histone H3 acetylation histone H4 acetylation histone H2B acetylation positive regulation of translation positive regulation of axon extension positive regulation of cell size positive regulation of proteolysis positive regulation of protein secretion cartilage development response to calcium ion regulation of angiotensin metabolic process positive regulation of sarcomere organization negative regulation of cell death protein-DNA complex assembly response to dexamethasone positive regulation of protein acetylation regulation of nucleic acid-templated transcription negative regulation of miRNA metabolic process liver development memory response to organic cyclic compound response to cobalt ion response to retinoic acid response to tumor necrosis factor cellular response to drug cellular response to trichostatin A response to hydrogen peroxide response to ethanol digestive tract development cellular response to hydrogen peroxide response to fatty acid cellular response to antibiotic cellular response to retinoic acid cellular response to cAMP cellular response to glucose stimulus cellular response to mineralocorticoid stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus cellular response to nerve growth factor stimulus
          It has to be done as per old AB suggested Products section.

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