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Invitrogen
CBX8 Polyclonal Antibody
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图: 1 / 2
CBX8 Antibody (PA5-103359) in ICC/IF
Immunofluorescent analysis of CBX8 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and CBX8 polyclonal antibody (Product # PA5-103359) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-103359
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CBX8(Accession Q9HC52), corresponding to amino acid residues R158-P208.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CBX8.
靶标信息
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: chromobox homolog 8; chromobox homolog 8 (Pc class homolog, Drosophila); Chromobox protein homolog 8; HPC3; mPc3; Pc3; Polycomb 3 homolog; Rectachrome 1
基因别名: CBX8; PC3; RC1
UniProt ID: (Mouse) Q9QXV1
Entrez Gene ID: (Mouse) 30951, (Rat) 303731
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of cell proliferation
chromatin modification
histone ubiquitination
positive regulation of collagen biosynthetic process
positive regulation of DNA repair
regulation of catalytic activity
cellular response to hydrogen peroxide
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