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Invitrogen
CCDC109B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-61817
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SNEHTAEMEH MKSLVHRLFT ILHLEESQKK REHHLLEKID HLKEQLQPLE QVKAGIEAHS E
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 74%.
靶标信息
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: coiled-coil domain containing 109B; coiled-coil domain-containing protein 109B; FLJ20647; mitochondrial calcium uniporter dominant negative beta subunit; mitochondrial calcium uniporter regulatory subunit MCUb; unnamed protein product
基因别名: CCDC109B
UniProt ID: (Human) Q9NWR8
Entrez Gene ID: (Human) 55013
mitochondrial calcium ion transport
calcium ion transmembrane import into mitochondrion
regulation of macrophage activation
skeletal muscle tissue regeneration
mitochondrial calcium ion homeostasis
negative regulation of calcium import into the mitochondrion
positive regulation of skeletal muscle satellite cell differentiation
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