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Abnova
CCDC115 Polyclonal Antibody, MaxPab™
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产品信息
H00084317-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CCDC115 (NP_115733.2, 1 a.a. approximately 180 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAALDLRAEL DSLVLQLLGD LEELEGKRTV LNARVEEGWL SLAKARYAMG AKSVGPLQYA SHMEPQVCLH ASEAQEGLQK FKVVRAGVHA PEEVGPREAG LRRRKGPTKT PEPESSEAPQ DPLNWFGILV PHSLRQAQAS FRDGLQLAAD IASLQNRIDW GRSQLRGLQE KLKQLEPGAA
靶标信息
The CCDC115 gene encodes a protein known as coiled-coil domain-containing protein 115, which is involved in cellular processes related to membrane trafficking and Golgi apparatus function. CCDC115 is integral to maintaining Golgi homeostasis and is implicated in the functioning of the vacuolar H+-ATPase (V-ATPase) proton pump, critical for acidifying intracellular compartments. Mutations in CCDC115 have been associated with a genetic condition known as congenital disorder of glycosylation type IIo (CDG-IIo), which leads to defects in protein glycosylation. This disorder results in a spectrum of symptoms, including developmental delays, neurological impairments, and multi-systemic dysfunction due to improper glycosylation of proteins, impacting their stability and function. Research indicates that CCDC115's activity in ion transport and vacuolar acidification is essential for Golgi apparatus function and overall cellular homeostasis. Investigations into CCDC115 are crucial for understanding its role in glycosylation-related disorders and for developing potential therapeutic strategies to manage these conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coiled-coil domain-containing protein 115
基因别名: CCDC115; ccp1; CDG2O
UniProt ID: (Human) Q96NT0
Entrez Gene ID: (Human) 84317
