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Invitrogen
CCDC14 Polyclonal Antibody
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CCDC14 Antibody (PA5-31759) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of CCDC14 was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: CCDC14 Polyclonal Antibody (Product # PA5-31759) diluted at 1:1000. Red: alpha Tubulin, a cytoskeleton marker. Blue: Hoechst 33342 staining.
产品信息
PA5-31759
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human CCDC14. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: 293T, A431, U87-MG, SK-N-SH, SK-N-AS.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CCDC14 (Coiled-Coil Domain-Containing 14) is a gene that encodes a protein involved in ciliary function and cellular division processes. This protein contains coiled-coil domains that facilitate protein-protein interactions crucial for the assembly and stabilization of microtubule structures within the cell. Research indicates that CCDC14 is essential for proper ciliogenesis, the process by which cells form cilia, which are vital for cell motility, fluid movement, and signal transduction. Additionally, studies have revealed its significant role in the regulation of cell cycle progression and cytokinesis. CCDC14 is required for the accurate segregation of chromosomes during cell division, ensuring genomic stability. Mutations or dysregulation of CCDC14 can lead to ciliopathies and other cellular dysfunctions, highlighting its critical role in maintaining normal cellular activities and its potential implications in various diseases.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Coiled-coil domain-containing protein 14
基因别名: CCDC14
UniProt ID: (Human) B8ZZ58
Entrez Gene ID: (Human) 64770
