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Invitrogen
CCL3 Recombinant Rabbit Monoclonal Antibody (013)
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产品信息
MA5-31275
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
013
抗原
Recombinant Rat CCL3/Mip1a Protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Rat CCL3/Mip1a.
靶标信息
Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C motif chemokine 3; H-MIP-1-alpha; LD78-alpha; Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); Macrophage inflammatory protein 1-alpha; MIP-1-alpha; mip1 alpha; RP23-320E6.7; small inducible cytokine A3; Small-inducible cytokine A3
基因别名: Ccl3; MIP-1a; Mip1a; Scya3
UniProt ID: (Rat) P50229
Entrez Gene ID: (Rat) 25542
protein kinase activity
calcium-dependent protein kinase C activity
chemokine activity
heparin binding
phospholipase activator activity
kinase activity
CCR1 chemokine receptor binding
CCR5 chemokine receptor binding
chemoattractant activity
identical protein binding
cytokine
intercellular signal molecule
MAPK cascade
osteoblast differentiation
cell activation
monocyte chemotaxis
protein phosphorylation
calcium ion transport
cellular calcium ion homeostasis
exocytosis
chemotaxis
inflammatory response
cytoskeleton organization
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
regulation of cell shape
response to toxic substance
positive regulation of gene expression
negative regulation of gene expression
T cell chemotaxis
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
calcium-mediated signaling
signaling
positive regulation of cell migration
negative regulation of bone mineralization
neutrophil chemotaxis
leukocyte chemotaxis
lipopolysaccharide-mediated signaling pathway
positive regulation of tumor necrosis factor production
response to drug
positive regulation of catalytic activity
eosinophil degranulation
protein kinase B signaling
positive regulation of neuron apoptotic process
astrocyte cell migration
negative regulation by host of viral transcription
negative regulation of osteoclast differentiation
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
eosinophil chemotaxis
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of interleukin-1 beta secretion
positive regulation of inflammatory response
positive regulation of calcium-mediated signaling
positive chemotaxis
positive regulation of protein kinase B signaling
positive regulation of calcium ion transport
regulation of sensory perception of pain
cell chemotaxis
positive regulation of ERK1 and ERK2 cascade
response to cholesterol
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to organic cyclic compound
granulocyte chemotaxis
positive regulation of natural killer cell chemotaxis
