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Invitrogen
CCL3 (MIP-1 alpha) Recombinant Rat Monoclonal Antibody (DNT3CC)
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CCL3 (MIP-1 alpha) Antibody (740116T) in Flow
Flow cytometry analysis of CCL3 (MIP-1 alpha) Recombinant Rat Monoclonal Antibody (DNT3CC) (Product # 740116T) was performed using RAW 264.7 cells treated with PMA (100 ng/mL, 16 hr), LPS (100 ng/mL, 4 hr) and Brefeldin A (1 µg/mL, 3 hr). Cells were fixed with eBioscience™ IC Fixation Buffer (Product # 00-8222-49) and stained with 0.0625 µg of the CCL3 (MIP-1 alpha) Recombinant Rat Monoclonal Antibody (DNT3... View More
产品信息
740116T
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
DNT3CC
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Recombinant rat monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C motif chemokine 3; H-MIP-1-alpha; Heparin-binding chemotaxis protein; L2G25B; LD78-alpha; Macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; MIP-1 alpha; MIP-1-alpha; MIP1 (a); mip1 alpha; RP23-320E6.7; SIS-alpha; small inducible cytokine A3; Small-inducible cytokine A3; TY-5
基因别名: AI323804; Ccl3; G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a); MIP1-alpha; Mip1a; Scya3
UniProt ID: (Mouse) P10855
Entrez Gene ID: (Mouse) 20302
chemotaxis
inflammatory response
immune response
positive regulation of cytosolic calcium ion concentration
regulation of cell shape
neutrophil chemotaxis
leukocyte chemotaxis
positive regulation of tumor necrosis factor production
positive regulation of neuron apoptotic process
astrocyte cell migration
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
macrophage chemotaxis
positive regulation of interleukin-1 beta secretion
positive regulation of inflammatory response
cell chemotaxis
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