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Invitrogen
CCL3 (MIP-1 alpha) Recombinant Rat Monoclonal Antibody (DNT3CC), Alexa Fluor™ Plus 555
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CCL3 (MIP-1 alpha) Antibody (740116TP555) in Flow
Flow cytometry analysis of CCL3 (MIP-1 alpha) Recombinant Rat Monoclonal Antibody (DNT3CC), Alexa Fluor™ Plus 555 (Product # 740116TP555) was performed using RAW 264.7 treated with LPS (100 ng/mL for 3 hr) and Brefeldin A (300 ng/mL for 3 hr) and untreated cells. Cells were fixed with eBioscience™ IC Fixation Buffer (Product # 00-8222-49), permeabilized and stained with 0.125 µg of CCL3 (MIP-1 alpha) Recomb... View More
产品信息
740116TP555
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a, kappa
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
DNT3CC
偶联物
Alexa Fluor™ Plus 555
Alexa Fluor™ Plus 555
Alexa Fluor™ Plus 555
激发/发射光谱
558/572 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
规格
50 µg
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 6.3-7.3
内含物
0.008% Bromonitrodioxane, 0.008% Methylisothiazolone
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Wet ice
产品详细信息
Alexa Fluor™ Plus recombinant antibodies are conjugated using new, proprietary dye chemistry so you can generate stunning data. Alexa Fluor™ Plus antibodies represent an advancement in fluorescent conjugate technology. Alexa Fluor™ Plus antibodies provide brighter signal compared to leading Alexa Fluor™ antibodies, providing you with better signal-to-noise for your critical experiments. These antibodies show better specificity and lot-to-lot consistency as these are recombinant antibodies, generated by cloning specific genes for the desired antibodies into an expression vector and expressed in vitro.
Using conjugate solutions: Centrifuge the protein conjugate solution briefly in a microcentrifuge before use; add only the supernatant to the experiment. This step will help eliminate any protein aggregates that may have formed during storage, thereby reducing nonspecific background staining.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Excitation: 553 nm; Emission: 568 nm; Laser: Yellow Laser
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C motif chemokine 3; H-MIP-1-alpha; Heparin-binding chemotaxis protein; L2G25B; LD78-alpha; Macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1alpha; MIP-1 alpha; MIP-1-alpha; MIP1 (a); mip1 alpha; RP23-320E6.7; SIS-alpha; small inducible cytokine A3; Small-inducible cytokine A3; TY-5
基因别名: AI323804; Ccl3; G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a); MIP1-alpha; Mip1a; Scya3
UniProt ID: (Mouse) P10855
Entrez Gene ID: (Mouse) 20302
chemotaxis
inflammatory response
immune response
positive regulation of cytosolic calcium ion concentration
regulation of cell shape
neutrophil chemotaxis
leukocyte chemotaxis
positive regulation of tumor necrosis factor production
positive regulation of neuron apoptotic process
astrocyte cell migration
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
macrophage chemotaxis
positive regulation of interleukin-1 beta secretion
positive regulation of inflammatory response
cell chemotaxis
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