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Invitrogen
CCL5 (RANTES) Monoclonal Antibody (21445), APC
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CCL5 (RANTES) Antibody (MA5-23557) in Flow
Flow cytometry of CCL5 (RANTES) in NS0 mouse myeloma cell line transfected with human CCL5/RANTES. Samples were incubated in CCL5 (RANTES) monoclonal antibody (Product # MA5-23557) or isotype control. To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer and permeabilized with Flow Cytometry Permeabilization/Wash Buffer.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-23557
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
21445
抗原
E. coli-derived recombinant human CCL5/RANTES
偶联物
APC
APC
APC
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
纯化类型
Protein A/G
保存液
Buffered saline solution with BSA
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs and Western blots, this antibody does not cross-react with other chemokines, including recombinant human CCL2, 3, 4 recombinant mouse (rm) CCL3, and rmCCL4.
靶标信息
CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C motif chemokine 5; EoCP; Eosinophil chemotactic cytokine; MGC17164; OTTHUMP00000197106; SIS δ; SIS-delta; SISδ; Small-inducible cytokine A5; T cell-specific protein P228; T-cell-specific protein RANTES; TCP228
基因别名: CCL5; D17S136E; SCYA5
Entrez Gene ID: (Human) 6352
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