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CCM2 Antibody (MA5-25669) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human endometrium tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a CCM2 monoclonal antibody (Product # MA5-25669).
产品信息
MA5-25669
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI1E9
抗原
Full length human recombinant protein of CCM2 produced in HEK293T cell
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2724050
靶标信息
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cerebral cavernous malformation 2; Cerebral cavernous malformations 2 protein; Malcavernin; MGC4067; MGC4607; MGC74868; Oncostatin; OncostatinM; osmosensing scaffold for MEKK3
基因别名: C7orf22; CCM2; OSM; PP10187
UniProt ID: (Human) Q9BSQ5
Entrez Gene ID: (Human) 83605
vasculogenesis
in utero embryonic development
endothelial cell development
integrin-mediated signaling pathway
multicellular organism growth
cell-cell junction organization
inner ear development
venous blood vessel morphogenesis
stress-activated MAPK cascade
pericardium development
blood vessel endothelial cell differentiation
endothelial tube morphogenesis
