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Invitrogen
CCR2 Recombinant Rabbit Monoclonal Antibody (HL2838)
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产品信息
MA5-56629
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2838
抗原
Synthetic peptide encompassing a sequence within the Extracellular domain of human CCR2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C chemokine receptor type 2; C-C CKR-2; Cc-ckr2; CD192; CD192 antigen; chemokine (C-C motif) receptor 2; hCG_14621; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
基因别名: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
UniProt ID: (Human) P41597
Entrez Gene ID: (Human) 729230
blood vessel remodeling
dendritic cell chemotaxis
inflammatory response to antigenic stimulus
positive regulation of T-helper 1 type immune response
negative regulation of type 2 immune response
cellular calcium ion homeostasis
chemotaxis
inflammatory response
immune response
cellular defense response
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
aging
response to wounding
response to ionizing radiation
regulation of vascular endothelial growth factor production
positive regulation of gene expression
positive regulation of T cell chemotaxis
negative regulation of angiogenesis
cytokine-mediated signaling pathway
cellular homeostasis
negative regulation of cell migration
negative regulation of axon extension
forebrain development
positive regulation of fever generation
response to lipopolysaccharide
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
T-helper 17 cell chemotaxis
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
negative regulation of eosinophil degranulation
fat cell differentiation
positive regulation of neuron differentiation
positive regulation of alpha-beta T cell proliferation
positive regulation of interleukin-1 beta secretion
positive regulation of inflammatory response
positive regulation of T cell activation
positive regulation of apoptotic process by virus
chemokine-mediated signaling pathway
neuron death
positive regulation of monocyte chemotaxis
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of immune complex clearance by monocytes and macrophages
negative regulation of neural precursor cell proliferation
positive regulation of monocyte extravasation
positive regulation of CD8-positive, alpha-beta T cell extravasation
positive regulation of astrocyte chemotaxis
positive regulation of hematopoietic stem cell migration
