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Invitrogen
CCR4 Polyclonal Antibody
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产品信息
PA5-99885
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CCR4(Accession P51679), corresponding to amino acid residues M1-L48.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CCR4.
靶标信息
CCR4 is a chemokine receptor and is preferentially expressed on type 2 helper T (Th2-type) cells. In contrast to other chemokine receptors, the expression of CCR4 and CCR8 on Th2 cells is transiently increased following TCR and CD28 engagement. Moreover, activated Th1 cells up-regulate CCR4 expression and functional responsiveness to thymus- and activation-regulated chemokine. Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C chemokine receptor type 4; C-C CKR-4; CCR-4; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; fusin; K5-5; leukocyte-expressed seven-transmembrane-domain receptor; MGC88293
基因别名: C-C CKR-4; CC-CKR-4; CCR4; CD194; CHEMR1; ChemR13; CKR4; CMKBR4; HGCN:14099; K5-5; LESTR; Sdf1r
UniProt ID: (Human) P51679, (Mouse) P51680
Entrez Gene ID: (Human) 1233, (Mouse) 12773
neuron migration
tolerance induction
chemotaxis
inflammatory response
immune response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
homeostasis of number of cells
chemokine-mediated signaling pathway
signal transduction
positive regulation of positive chemotaxis
