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产品信息
PA5-94947
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human CCR6 (358-374aa RQTSETADNDNASSFTM).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2806753
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
CCR6 is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C chemokine receptor type 6; C-C CKR-6; CC chemokine receptor 6; CD196; chemokine (C-C motif) receptor 6; chemokine (C-C) receptor 6; Chemokine receptor-like 3; CKR-L3; CKR6; DRY-6; DRY6; G protein-coupled receptor 29; G-protein coupled receptor 29; GPR-CY4; GPRCY4; KY411; LARC receptor; seven-transmembrane receptor, lymphocyte, 22
基因别名: BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CCR6; CD196; CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; KY411; STRL22
UniProt ID: (Human) P51684, (Mouse) O54689
Entrez Gene ID: (Human) 1235, (Rat) 308163, (Mouse) 12458
chemotaxis
immune response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of epithelial cell migration
chemokine-mediated signaling pathway
positive regulation of dendritic cell chemotaxis
dendritic cell chemotaxis
leukocyte migration involved in inflammatory response
movement of cell or subcellular component
humoral immune response
cellular defense response
signal transduction
calcium-mediated signaling
isotype switching to IgA isotypes
cell chemotaxis
positive regulation of sperm motility involved in capacitation
lymphocyte migration
T cell migration
thymocyte migration
DN2 thymocyte differentiation
DN3 thymocyte differentiation
regulation of T cell migration
