Invitrogen

CCR7 Recombinant Rabbit Monoclonal Antibody (5U7S5)

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说明书
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CCR7 Recombinant Rabbit Monoclonal Antibody (5U7S5)

产品信息

MA5-35047

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:6,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:100-1:400
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

5U7S5

抗原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR7 (P32248)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.2 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2848952

产品详细信息

Immunogen sequence: MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL

靶标信息

CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: BLR2; Bukitt's lymphoma receptor 2; C-C chemokine receptor type 7; C-C CKR-7; CC chemokine receptor 7; CD197; CDw197; chemokine (C-C motif) receptor 7; chemokine (C-C) receptor 7; EBI1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor

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基因别名: BLR2; CC-CKR-7; CCR-7; CCR7; CD197; CDw197; CMKBR7; EBI1; Ebi1h; EVI1

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UniProt ID: (Human) P32248, (Mouse) P47774

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Entrez Gene ID: (Human) 1236, (Rat) 287673, (Mouse) 12775

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功能
G-protein coupled receptor activity C-C chemokine receptor activity chemokine (C-C motif) ligand 19 binding chemokine (C-C motif) ligand 21 binding C-C motif chemokine 19 receptor activity C-C motif chemokine 21 receptor activity signal transducer activity chemokine receptor activity protein binding
参与通路
myeloid dendritic cell chemotaxis positive regulation of dendritic cell antigen processing and presentation positive regulation of hypersensitivity positive regulation of humoral immune response chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway response to lipopolysaccharide regulation of interferon-gamma production positive regulation of interleukin-12 production chemokine (C-C motif) ligand 19 signaling pathway chemokine (C-C motif) ligand 21 signaling pathway negative thymic T cell selection regulation of interleukin-1 beta secretion positive regulation of T cell receptor signaling pathway chemokine-mediated signaling pathway cellular response to cytokine stimulus interleukin-12 secretion positive regulation of neutrophil chemotaxis mature conventional dendritic cell differentiation positive regulation of dendritic cell chemotaxis positive regulation of immunological synapse formation positive regulation of T cell costimulation positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation establishment of T cell polarity positive regulation of cell-matrix adhesion dendritic cell chemotaxis positive regulation of cytosolic calcium ion concentration positive regulation of actin filament polymerization positive regulation of pseudopodium assembly ruffle organization response to prostaglandin E positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of phosphatidylinositol 3-kinase activity positive regulation of cell adhesion positive regulation of protein kinase activity positive regulation of JNK cascade homeostasis of number of cells release of sequestered calcium ion into cytosol positive regulation of filopodium assembly positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade response to nitric oxide activation of GTPase activity lymphocyte migration into lymph node negative regulation of leukocyte apoptotic process positive regulation of cell motility regulation of dendritic cell dendrite assembly lymphocyte chemotaxis across high endothelial venule regulation of tolerance induction to self antigen signal transduction activation of JUN kinase activity positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis actin cytoskeleton organization positive regulation of tumor necrosis factor production positive regulation of T cell proliferation positive regulation of GTPase activity positive regulation of T-helper 1 cell differentiation positive regulation of receptor-mediated endocytosis lymph node development positive regulation of interleukin-1 beta secretion positive regulation of phagocytosis positive regulation of thymocyte migration
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