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Invitrogen
CD101 Recombinant Rabbit Monoclonal Antibody (5D6V4)
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CD101 Antibody (MA5-55405) in WB
Western blot analysis of lysates from 293T-CD101 cells, using CD101 Recombinant Monoclonal Antibody (Product # MA5-55405) at 1:1,000 dilution followed by a HRP-conjugated Goat anti-Rabbit IgG (H+L) secondary antibody at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
MA5-55405
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5D6V4
抗原
Recombinant protein (or fragment)
偶联物
形式
Liquid
浓度
1.08 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
RRID
产品详细信息
Immunogen Sequence: QREVTVQKGP LFRAEGYPVS IGCNVTGHQG PSEQHFQWSV YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ GNSVLLHISK LQMKDAGEYE CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT MSSQTLGKEE GEPLALTCEA SKATAQHTHL SVTWYLTQDG GGSQATEIIS LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ SSDQGQLFCE ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL QVSKLGPKAF SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD SHVHLRKPAA
靶标信息
CD101, also known as the V7 antigen, is a transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is characterized by 7 Ig-like IgV domains and a short cytoplasmic tail with several phosphorylation sites. CD101 forms a disulfide-linked homodimer, although its precise function remains unknown. Expression of CD101 is observed on monocytes, granulocytes, dendritic cells, Langerhans cells, and activated T cells. It is also found on a subset of CD25+Foxp3+ regulatory T cells, which exhibit higher suppressive properties in vitro and in vivo. CD101 plays a role in modulating immune responses. Cross-linking CD101 can antagonize TCR/CD3-mediated lymphocyte activation, while CD101+ CD28+ T cells are highly responsive to CD28 signaling. In combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can enhance proliferation, suggesting an activating role. The monoclonal antibody BB27 has been shown to inhibit T cell reactivity in allogeneic and antigen-specific mixed DC-T cell cultures. In mice, CD101 is expressed on a subpopulation of regulatory T cells (CD4+, CD25+, Foxp3+) with high suppressor activity. In humans, CD101 expression on peripheral blood mononuclear cells (PBMCs) stains approximately 30% of Foxp3+ cells, although studies have not confirmed higher suppressor activity in the human CD101+ population.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD101; Cell surface glycoprotein V7; EWI-101; Glu-Trp-Ile EWI motif-containing protein 101; IgSF2; Immunoglobulin superfamily member 2; leukocyte surface protein; RP11-27K13.2
基因别名: CD101; EWI-101; EWI101; IGSF2; V7
UniProt ID: (Human) Q93033
Entrez Gene ID: (Human) 9398
