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Invitrogen
CD122/CD132 Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-58661
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Singapore ASTR patent anti-IL-2R beta/IL-2R gamma .
靶标信息
CD122 and CD132 are integral subunits of the interleukin-2 receptor (IL-2R) complex, which also includes the alpha chain (CD25). They are respectively known as the beta chain (CD122) and the gamma chain (CD132). These genes are expressed in various cell types and are crucial for immunological responses. The heterodimeric CD122/CD132 receptor subunits are vital for the signal transduction of interleukins like IL-2 and IL-15, which are critical for T cell proliferation and activation. CD122, in particular, has an extensive intracellular region, making it indispensable for downstream signaling. Both CD122 and CD132 contribute to the receptor's function by binding IL-2 and other cytokines, facilitating their role in immune regulation and homeostasis. Studies suggest that CD122 and CD132 may be expressed by fibroblast-like synoviocytes (FLS) and dermal fibroblasts (DF), underscoring their broader biological significance beyond immune cells. This receptor complex is also a focal point in cancer immunotherapy strategies due to its role in modulating T regulatory cells (Tregs) and effector T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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