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IL-3Ra (Interleukin-3 receptor subunit alpha) belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit. IL-3Ra is responsible for the transmission of signal of Interleukin-3. IL-3Ra and IL-3Rb chain heterodimerization is induced by Interleukin-3, which is required for receptor activation but not high affinity binding. IL-3Ra is also reported that IL-3Ra subunits are overexpressed on acute myeloid leukemia (AML) blasts compared with normal hematopoietic cells and are thus potential targets for novel therapeutic agents.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
蛋白别名: CD123; CD123 antigen; IL-3 receptor subunit alpha; IL-3R subunit alpha; interleukin 3 receptor, alpha (low affinity); Interleukin-3 receptor subunit alpha; membrane protein; unnamed protein product
基因别名: CD123; hIL-3Ra; IL-3R-alpha; IL3R; IL3RA; IL3RAY; IL3RX; IL3RY
UniProt ID: (Human) P26951
Entrez Gene ID: (Human) 3563