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Invitrogen
CD137 Chimeric Recombinant Rabbit Monoclonal Antibody (LOB12.3)
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CD137 Chimeric Antibody (MA5-48147) in ELISA
ELISA analysis of CD137 chimeric monoclonal antibody (Product # MA5-48147) was performed by coating plate with Mouse IgE-Fc (blue line), Dog IgE-Fc (orange line) and Mouse 4-1BB Fc-Fusion Protein (grey line) at a concentration of 2.5 µg/mL. A 3-fold serial dilution from 3,000 to 0.0169 ng/mL of the antibody was done. For signal detection, a 1:4,000 dilution of a HRP-conjugated anti-rabbit IgG antibody was used.
产品信息
MA5-48147
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
LOB12.3
抗原
This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: This antibody binds to mouse 4-1BB (CD137).
靶标信息
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 4 1 BB; 4-1BB ligand receptor; 41BB; CD137; CD137 antigen; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T-cell antigen 4-1BB; Tumor necrosis factor receptor superfamily member 9
基因别名: 4-1BB; A930040I11Rik; AA408498; AI325004; Cd137; CDw137; ILA; Ly63; Tnfrsf9
UniProt ID: (Mouse) P20334
Entrez Gene ID: (Mouse) 21942
