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Invitrogen
CD14 Monoclonal Antibody (VPM67)
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产品信息
MA5-28291
应用
建议稀释比
已发表文章
产品规格
种属反应
Sheep
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
VPM67
抗原
Ovine macrophages
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Mouse anti Sheep CD14 monoclonal antibody, clone VPM67 recognizes ovine CD14, a GPI-anchored approximately 55 kDa membrane glycoprotein and monocyte/macrophage differentiation antigen, belonging to the lipopolysaccharide receptor family.
靶标信息
CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD 14; cd14 monocyte; lipopolysaccharide receptor; lipoprotein receptor; LPSR antibody; sCD14; soluble CD14
Entrez Gene ID: (Sheep) 443216
