Invitrogen

CD150 Recombinant Rabbit Monoclonal Antibody (8)

Name: CD150 Recombinant Rabbit Monoclonal Antibody (8)
Brand: Invitrogen
SKU: MA5-29571

查看其他40个CD150抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

CD150 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD150 Antibody (MA5-29571) in IHC (P)

Immunohistochemical staining of human CD150 in human lymph node with CD150 Recombinant Rabbit Monoclonal Antibody (8) (Product # MA5-29571, 1:2,000, formalin-fixed paraffin embedded sections).

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Immunogen image

Immunogen Image CD150 Recombinant Rabbit Monoclonal Antibody (8)

产品信息

MA5-29571

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:1,000-1:4,000

酶联免疫吸附实验 (ELISA)

1:5,000-1:10,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

抗原

Recombinant Human CD150 protein (Met1-Pro258)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2785413

产品详细信息

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This antibody has specificity for Human SLAMF1/CD150/SLAM.

靶标信息

CD150, also known as SLAM (Signaling Lymphocyte Activation Molecule), is a member of the immunoglobulin gene superfamily and plays a crucial role in T cell stimulation and immune cell interactions. It is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells. CD150 expression is rapidly upregulated upon activation, particularly on naive T cells, Th1 cells, and activated B cells, which express the membrane-bound, soluble, and cytoplasmic isoforms of SLAM. In T cells, signaling through SLAM induces proliferation and enhances the interferon-gamma response. SLAM is also involved in adhesion between T cells and antigen-presenting cells, facilitating immune cell interactions. Homophilic SLAM-SLAM binding during B to B and B to T cell interactions is suggested to enhance the expansion and differentiation of activated B cells. CD150 serves as a receptor for the measles virus and acts as a co-activator on T and B cells. It interacts with SH2D1A and PTPN11 via its cytoplasmic domain, playing a role in signal transduction. Mutations in the CD150 gene may be associated with X-linked lymphoproliferative disease (XLP), highlighting its importance in immune regulation and disease pathology.

仅用于科研。不用于诊断过程。未经明确授权不得转售。