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This antibody recognizes an extracellular epitope of CD150, a cell surface molecule expressed on lymphocytes and involved in their activation.
CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily, and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. Moreover, CD150 is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations CD150 gene may be associated with X-linked lympho-proliferative disease (XLP).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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蛋白别名: CD150; CD150 antigen; CDw150; IPO-3; Signaling lymphocytic activation molecule; SLAM family member 1
基因别名: CD150; CDw150; SLAM; SLAMF1
UniProt ID: (Human) W0HKK7
Entrez Gene ID: (Human) 6504