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Invitrogen
CD156A/EGFR Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-60143
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 0.01% Tween 80, 8% sucrose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
The CD156A gene, also known as ADAM8 (a disintegrin and metalloprotease 8), is a cell surface antigen highly expressed in monocytic lineages, with a significant role in neurodegenerative diseases and cancer. It is a membrane-anchored metalloprotease with a long extracellular region containing domains similar to hemorrhagic snake venom proteins. ADAM8 is involved in the regulation of cell adhesion and proteolysis. The gene encoding CD156A is located on human chromosome 10q26.3. Meanwhile, the EGFR gene, or epidermal growth factor receptor, is part of the ErbB family of receptor tyrosine kinases located on chromosome 7p11.2. EGFR plays a crucial role in regulating cell proliferation, differentiation, survival, and migration. It is a 170-kDa transmembrane glycoprotein and is heavily implicated in various cancers, including non-small-cell lung cancer and glioblastoma due to mutations or overexpressions. Both genes are critical for cell communication and regulation processes, with significant implications for cancer therapy and neurodegenerative disease research.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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