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Invitrogen
CD183 (CXCR3) Recombinant Mouse Monoclonal Antibody (CEW33D)
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CD183 (CXCR3) Antibody (740160M) in Flow
Flow cytometry analysis of CD183 (CXCR3) Recombinant Mouse Monoclonal Antibody (CEW33D) (Product # 740160M) was performed using Human PBMCs differentiated to Th1. Differentiated Th1 cells were stained with CD3 Monoclonal Antibody (UCHT1), eFluor™ 450, eBioscience™ (Product # 48-0038-42) and 0.25 µg of CD183 (CXCR3) Recombinant Mouse Monoclonal Antibody (CEW33D) (Product # 740160M) (Fig. b) or Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eBioscience™ (Product # 14-4714-82) (Fig. a), followed by Goat anti-Mouse IgG (H+L) Superclonal™ Secon... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
740160M
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
CEW33D
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Recombinant mouse monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
CD183, also known as CXCR3, is a seven-transmembrane G protein-coupled chemokine receptor that binds CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC), which are part of the CXC chemokine subfamily. CD183 plays a crucial role in leukocyte traffic, influencing integrin activation, cytoskeletal changes, and chemotactic migration. It is expressed on NK cells, subsets of T lymphocytes, regulatory T cells (Tregs), and is preferentially found on Th1-polarized cells. CD183 is prominently expressed in effector/memory T cells and T cells in inflamed tissues, contributing to CD4 T cell responses to grafts, as evidenced by compromised allograft rejection in CXCR3 knockout mice. Chemokine binding induces rapid, short-lived cellular responses due to receptor internalization, with responsiveness restored after receptor recycling. Inhibition by Bordetella pertussis toxin suggests coupling with Gi subclass G proteins. The production of IP-10, Mig, and I-TAC in inflammatory lesions indicates CD183 role in recruiting inflammatory cells, making it a target for developing antagonists to treat inflammatory diseases. Multiple transcript variants encoding different isoforms of CD183 have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: an; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C motif) receptor 3 isoform CXCR3_1; chemokine (C-X-C motif) receptor 3 isoform CXCR3_2; chemokine receptor 3; CXC; CXC motif chemokine; CXCR3-B; G protein-coupled receptor; G protein-coupled receptor; G protein-coupled receptor 9; interferon-inducible protein 10 receptor; IP-10 receptor; IP10; IP10 receptor; Mig receptor; unnamed protein product
基因别名: CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R; Mig-R; MigR
UniProt ID: (Human) P49682
Entrez Gene ID: (Human) 2833
negative regulation of endothelial cell proliferation
regulation of leukocyte migration
chemotaxis
inflammatory response
immune response
cell adhesion
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
T cell chemotaxis
negative regulation of angiogenesis
calcium-mediated signaling
regulation of cell adhesion
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
positive regulation of chemotaxis
positive regulation of release of sequestered calcium ion into cytosol
cell chemotaxis
chemokine-mediated signaling pathway
negative regulation of execution phase of apoptosis
positive regulation of execution phase of apoptosis
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