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Invitrogen
CD19/CD47 (Zeripatamig Biosimilar) Recombinant Human Monoclonal Antibody
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CD19/CD47 (Zeripatamig Biosimilar) Antibody (MA562504) in SDS-PAGE
SDS-PAGE analysis of CD19/CD47 (Zeripatamig Biosimilar). Samples were run under reducing (R) and non-reducing (NR) conditions using CD19/CD47 (Zeripatamig Biosimilar) (Product # MA562504) monoclonal antibody. The purity of the protein is greater than 95%.
产品信息
MA562504
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa/IgG1, lambda
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
CD19 is an immunoglobulin superfamily protein with two Ig-like domains. It is expressed on B cells at all stages of development except terminal plasma cells, and is also found on follicular dendritic cells and some myeloid leukemia cells. As the earliest and most broadly expressed B cell marker, CD19 is present in all B cell precursor leukemias. CD19 forms a signaling complex with CD21, CD81, Leu13, MHC class II, and the B cell receptor (BCR). It functions as a key BCR co-receptor, amplifying signals and lowering the activation threshold, allowing B cells to respond even to low-affinity antigens. CD19 signaling triggers tyrosine phosphorylation, calcium mobilization, and B cell proliferation. It can also act independently as a central signaling regulator integrating multiple pathways. CD19 is essential for normal immune responses and malignant B cell growth. Mutations can cause hypogammaglobulinemia (low antibody levels), while overexpression may lead to B cell hyperactivity. It is expressed on virtually all peripheral B cells.
CD47, also known as integrin-associated protein (IAP), is a widely expressed glycosylated transmembrane protein found on hematopoietic cells (T cells, B cells, monocytes, platelets, erythrocytes) and many non-hematopoietic cells. It interacts with integrins and serves as a receptor for thrombospondin, influencing cell signaling, migration, and synaptic activity. CD47 binds to SIRPα (CD172a) on macrophages, delivering a “don’t eat me” signal that inhibits phagocytosis of CD47-positive cells. CD47 also regulates B cell adhesion, T cell activation, neuronal development, and responses to mechanical stress in cartilage. In T cells, thrombospondin binding can promote activation or apoptosis. Antibody engagement of CD47 can induce suppressive T cell activity and increase Foxp3 expression. Its broad distribution and signaling roles highlight its importance in immune regulation and other physiological processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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