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NeoBiotechnologies
CD2/Lymphocyte Function Antigen 2 (LFA-2) Recombinant Rabbit Monoclonal Antibody (LFA2, 3417R)
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CD2/Lymphocyte Function Antigen 2 (LFA-2) Antibody (914-RBM7-P1ABX) in IHC (P)
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human brain using CD2, Lymphocyte Function Antigen 2 (LFA-2) Recombinant Monoclonal Antibody (Product # 914-RBM7-P1ABX) at 2 µg/mL in PBS for 30 min RT. HIER: Tris/EDTA, pH9.0, 45 min. Secondary: HRP-polymer, 30 min. DAB, 5 min.
产品信息
914-RBM7-P1ABX
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
LFA2, 3417R
抗原
Synthetic peptide corresponding to residues within N-terminal of CD2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD2; CD2 antigen (p50), sheep red blood cell receptor; CD2 surface antigen; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; lymphocyte-function antigen-2; Rosette receptor; surface antigen CD2 precursor; T-cell surface antigen CD2; T-cell surface antigen CD2 precursor; T-cell surface antigen T11/Leu-5; unnamed protein product
基因别名: CD2; LFA-2; SRBC; T11
UniProt ID: (Human) P06729
Entrez Gene ID: (Human) 914
membrane raft polarization
apoptotic process
immune response
cell adhesion
cell surface receptor signaling pathway
natural killer cell activation
positive regulation of myeloid dendritic cell activation
positive regulation of interferon-gamma production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
heterotypic cell-cell adhesion
T cell activation
natural killer cell mediated cytotoxicity
regulation of T cell differentiation
cell-cell adhesion
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