Search
Invitrogen
CD20/CD47 (Amulirafusp Alfa Biosimilar) Recombinant Human Monoclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
产品信息
MA562507
产品规格
种属反应
Human
宿主/亚型
Human
/ Ig Mix
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA562507 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.
靶标信息
CD20 is a non-glycosylated surface phosphoprotein (33-37 kDa) expressed on mature and most malignant B cells, as well as on a subset of T cells and follicular dendritic cells. Its expression parallels surface IgM on B cells and it helps regulate calcium transport, cell cycle progression, and B cell proliferation. CD20 is associated with lipid rafts, and this association can change after extracellular stimulation or B cell receptor (BCR) engagement. Following receptor ligation, CD20 and the BCR briefly colocalize, then separate before BCR internalization; CD20 remains on the cell surface. Because it is highly expressed on most B cell malignancies and is not rapidly internalized or shed after antibody binding, CD20 is an effective target for therapeutic antibody-mediated B cell depletion. Alterations in CD20 (MS4A1) are linked to certain immune deficiencies, including common variable immune deficiency.
CD47, also called integrin-associated protein (IAP), is a widely expressed glycosylated transmembrane protein found on hematopoietic cells (T cells, B cells, monocytes, platelets, erythrocytes) and many non-hematopoietic cells. It interacts with integrins and acts as a receptor for thrombospondin, mediating bidirectional signaling that influences synaptic activity and immune cell function. CD47 binds to SIRPα (CD172a) on macrophages, delivering a “don’t eat me” signal that prevents phagocytosis of CD47-expressing cells. It also regulates cell migration, B cell adhesion, T cell activation, neuronal development, and cartilage responses to mechanical stress. In T cells, thrombospondin engagement can promote activation or apoptosis. Antibody stimulation of CD47 can induce suppressive T cell activity and increase Foxp3 expression. Its broad expression and signaling roles highlight its importance in immune regulation and other physiological processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
