NeoBiotechnologies

CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Monoclonal Antibody (TEK/9411)

Name: CD202b\/TIE2\/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Monoclonal Antibody (TEK\/9411)
Brand: NeoBiotechnologies
SKU: 7010-MSM10-P1

查看其他52个TIE2 (TEK)抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 3

CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Antibody (7010-MSM10-P1) in IHC (P)

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with TEK Mouse Monoclonal Antibody (TEK/9411). Inset: PBS instead of primary antibody; secondary only negative control.

CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Antibody in SDS-PAGE (SDS-PAGE)

Product Image Gallery

Immunogen image

Immunogen Image CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Monoclonal Antibody (TEK/9411)

产品信息

7010-MSM10-P1

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

TEK/9411

抗原

Recombinant fragment (around aa 700-1000) of human TEK protein (exact sequence is proprietary).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product cellular localization: Nucleus.

Positive control: Human kidney, pancreas or liver tissue.

靶标信息

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Angiopoietin-1 receptor; CD202b; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; hTIE2; p140 TEK; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2

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基因别名: CD202B; TEK; TIE-2; TIE2; VMCM; VMCM1

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UniProt ID: (Human) E7EWI2

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Entrez Gene ID: (Human) 7010

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功能

protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding growth factor binding transmembrane signal receptor

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