NeoBiotechnologies

CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Monoclonal Antibody (TEK/9411)

Name: CD202b\/TIE2\/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Monoclonal Antibody (TEK\/9411)
Brand: NeoBiotechnologies
SKU: 7010-MSM10-P1ABX

查看其他52个TIE2 (TEK)抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 3

CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Antibody (7010-MSM10-P1ABX) in IHC (P)

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with TEK Mouse Monoclonal Antibody (TEK/9411). Inset: PBS instead of primary antibody; secondary only negative control.

CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Antibody in SDS-PAGE (SDS-PAGE)

Product Image Gallery

Immunogen image

Immunogen Image CD202b/TIE2/TEK (Tyrosine Kinase with Ig and EGF Homology Domains 2) Monoclonal Antibody (TEK/9411)

产品信息

7010-MSM10-P1ABX

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

TEK/9411

抗原

Recombinant fragment (around aa 700-1000) of human TEK protein (exact sequence is proprietary).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein G

保存液

PBS

内含物

no preservative

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product cellular localization: Cell membrane, Cytoplasm, Secreted.

Positive control: Human lung, placenta or spleen.

Tissue specificity: Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.

靶标信息

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Angiopoietin-1 receptor; CD202b; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; hTIE2; p140 TEK; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor TIE-2

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基因别名: CD202B; TEK; TIE-2; TIE2; VMCM; VMCM1

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UniProt ID: (Human) E7EWI2

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Entrez Gene ID: (Human) 7010

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功能

protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding growth factor binding transmembrane signal receptor

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