NeoBiotechnologies

CD209/DC-SIGN (Pathogen Receptor on Dendritic Cells) Recombinant Rabbit Monoclonal Antibody (C209, 2749R)

Name: CD209\/DC-SIGN (Pathogen Receptor on Dendritic Cells) Recombinant Rabbit Monoclonal Antibody (C209, 2749R)
Brand: NeoBiotechnologies
SKU: 30835-RBM2-P1ABX

查看其他56个DC-SIGN (CD209)抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

CD209/DC-SIGN (Pathogen Receptor on Dendritic Cells) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD209/DC-SIGN (Pathogen Receptor on Dendritic Cells) Antibody (30835-RBM2-P1ABX) in IHC (P)

Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human small intestine using CD209, DC-SIGN (Pathogen Receptor on Dendritic Cells) Recombinant Monoclonal Antibody (Product # 30835-RBM2-P1ABX).

CD209/DC-SIGN (Pathogen Receptor on Dendritic Cells) Antibody in SDS-PAGE (SDS-PAGE)

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Immunogen image

Immunogen Image CD209/DC-SIGN (Pathogen Receptor on Dendritic Cells) Recombinant Rabbit Monoclonal Antibody (C209, 2749R)

产品信息

30835-RBM2-P1ABX

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

C209, 2749R

抗原

Recombinant full-length human CD209 protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

靶标信息

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; CD209; CD209 antigen; DC-SIGN; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; HIV gpl20-binding protein; MGC129965; MGC130443

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基因别名: CD209; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1

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UniProt ID: (Human) Q9NNX6

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Entrez Gene ID: (Human) 30835

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功能

virus receptor activity protein binding mannose binding carbohydrate binding peptide antigen binding virion binding metal ion binding membrane traffic protein

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