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CD22/CD3 (Rezetamig Biosimilar) Recombinant Human Monoclonal Antibody
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CD22/CD3 (Rezetamig Biosimilar) Antibody (MA5-54976) in ELISA
ELISA binding of CD22/CD3 (Rezetamig Biosimilar) to immobilized recombinant antigen (coated at 5 µg/mL). CD22/CD3 (Rezetamig Biosimilar) monoclonal (Product # MA5-54976) antibody was serially diluted from 10,000 ng/mL to 0.64 ng/mL.
产品信息
MA5-54976
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Recombinant Human CD22 and CD3E.
偶联物
形式
Liquid
浓度
4.21 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Compatible with Direct ELISA
靶标信息
CD22 (BL-CAM) is a type I transmembrane glycoprotein expressed mainly on mature B cells and many B cell lymphomas, including hairy cell leukemia and diffuse large B cell lymphoma, but not classical Hodgkin lymphoma. It exists as two isoforms (CD22α and CD22β, 130 and 140 kDa) generated by alternative splicing. The extracellular region contains seven Ig-like domains that bind α2,6-linked sialic acids on epithelial, endothelial, B, and T cells. These interactions may be masked by binding to sialic acids on the same cell (cis interactions). CD22 expression occurs in later stages of B cell development, making it useful for identifying mature B cell leukemias. Its cytoplasmic tail contains six tyrosine residues within immunotyrosine-based inhibitory motifs (ITIMs) and activation-like motifs. Upon B cell receptor (BCR) engagement, these residues are phosphorylated. CD22 can positively regulate signaling through Src family kinases and negatively regulate it by recruiting phosphatases via SH2 domains, which dampen BCR signaling. Through this dual regulatory role, CD22 helps fine-tune B cell activation and serves as an important diagnostic and research marker.
The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for T cell receptor (TCR) assembly and surface expression. These immunoglobulin superfamily proteins are encoded by closely linked genes on chromosome 11. CD3 is expressed on thymocytes and all mature T cells, but not on B or NK cells. CD3 transmits antigen-recognition signals into T cells via tyrosine-based motifs in its cytoplasmic tails. TCR crosslinking activates intracellular pathways that lead to T cell activation, proliferation, survival, or growth arrest. CD3 defects cause immunodeficiency, underscoring its critical role in immune function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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