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Invitrogen
CD230 (PrP) Monoclonal Antibody (ROS-BC6)
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FIGURE: 1 / 1
CD230 (PrP) Antibody (MA5-28326) in WB
Western blot analysis of CD230 (PrP) in ovine medulla and spleen. Sample was incubated with CD230 (PrP) monoclonal antibody (Product # MA5-28326). Images shown are as follows: 1) PRP c BSE infected ovine medulla, 2) PRP c uninfected ovine medulla, 3) Scrapie infected ovine medulla, 4) PRP sc scrapie infected ovine spleen, 5) PRP sc BSE infected ovine medulla, 6) PRP sc BSE infected ovine spleen.
Product Details
MA5-28326
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Sheep
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
ROS-BC6
Immunogen
A truncated form of recombinant Ovine PRP spanning residues aa94 - aa233
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Mouse anti Sheep CD230 (Prpsc) antibody, clone ROS-BC6 recognizes the prion disease form of prion protein known as CD230.
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BSE; CD230; Major prion protein; MGC26679; PK resistant core; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); PrP; PrPc; TSE
Gene Aliases: PRNP; PRP; PRPC; SIP
UniProt ID: (Sheep) P23907
Entrez Gene ID: (Sheep) 493887
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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