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Invitrogen
CD244 Recombinant Mouse Monoclonal Antibody (eBioDM244)
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CD244 Antibody (740136M) in Flow
Flow cytometry analysis of CD244 Recombinant Mouse Monoclonal Antibody (eBioDM244) (Product # 740136M) was performed using Human PBMCs. Human PBMCs were stained with CD56 (NCAM) Monoclonal Antibody (CMSSB), APC, eBioscience™ (Product # 17-0567-42) and 0.25 µg of CD244 Recombinant Mouse Monoclonal Antibody (eBioDM244) (Product # 740136M) (Fig. b) or 0.25 µg of Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eBioscience™ (Product #14-4714-85) (Fig. a), followed by Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor™ 488 (Pr... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
740136M
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
eBioDM244
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
Recombinant mouse monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alternatively spliced; CD244; CD244 molecule, natural killer cell receptor 2B4; cell surface glycoprotein; immunoglobulin superfamily; h2B4; NAIL; Natural killer cell receptor 2B4; NK cell activation inducing ligand NAIL; NK cell activation-inducing ligand; NK cell type I receptor protein 2B4; NKR Nmrk; NKR2B4; Signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4; unnamed protein product
基因别名: 2B4; CD244; NAIL; NKR2B4; Nmrk; SLAMF4
UniProt ID: (Human) Q9BZW8
Entrez Gene ID: (Human) 51744
adaptive immune response
natural killer cell activation involved in immune response
immune system process
immune response
signal transduction
natural killer cell activation
positive regulation of interferon-gamma production
positive regulation of interleukin-8 production
innate immune response
positive regulation of inositol phosphate biosynthetic process
positive regulation of granzyme B production
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
