Invitrogen

CD28 Monoclonal Antibody (CD28.2)

Name: CD28 Monoclonal Antibody (CD28.2)
Brand: Invitrogen
SKU: MA1-20792

6 篇参考文献

查看其他138个CD28抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image CD28 Monoclonal Antibody (CD28.2)

产品信息

MA1-20792

应用

建议稀释比

已发表文章

免疫组化（冰冻） (IHC (F))

Assay-dependent

免疫细胞化学 (ICC/IF)

Assay-dependent

流式细胞分析 (Flow)

Assay-dependent

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免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Baboon, Chimpanzee, Cynomolgus monkey, Human, Mouse, Non-human primate, Rhesus monkey

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

CD28.2

抗原

Human CD28 transfected murine T cell hybridoma.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

AB_558160

产品详细信息

MA1-20792 detects CD28 in human and non-human primate samples.

靶标信息

CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary's Disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CD28; CD28 antigen; CD28 precursor 6m; CD28 precursor P; CD28 precursor protein; MFASCD28-6m; MGC138290; sCD28; soluble CD28; T-cell-specific surface glycoprotein CD28; T44; TP44

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基因别名: CD28; EGK_04709; MFASCD28-P; Tp44

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UniProt ID: (Human) P10747, (Mouse) P31041